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Piotr Jachimczak Selected Research

Trabedersen

12/2011TGF-β2 signaling in high-grade gliomas.
12/2011The antisense oligonucleotide trabedersen (AP 12009) for the targeted inhibition of TGF-β2.
11/2009Treatment of malignant gliomas with TGF-beta2 antisense oligonucleotides.
1/2007Inhibition of TGF-beta2 with AP 12009 in recurrent malignant gliomas: from preclinical to phase I/II studies.
2/2006Targeted tumor therapy with the TGF-beta 2 antisense compound AP 12009.
1/2005Intracerebral and intrathecal infusion of the TGF-beta 2-specific antisense phosphorothioate oligonucleotide AP 12009 in rabbits and primates: toxicology and safety.

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Piotr Jachimczak Research Topics

Disease

7Glioma (Gliomas)
12/2011 - 09/2002
6Neoplasms (Cancer)
11/2013 - 02/2006
4Neoplasm Metastasis (Metastasis)
11/2013 - 09/2002
4Melanoma (Melanoma, Malignant)
11/2013 - 09/2002
1Carcinogenesis
12/2011
1Glioblastoma (Glioblastoma Multiforme)
12/2011
1Pancreatic Neoplasms (Pancreatic Cancer)
12/2011
1Colorectal Neoplasms (Colorectal Cancer)
12/2011
1Astrocytoma (Pilocytic Astrocytoma)
11/2009
1Brain Neoplasms (Brain Tumor)
01/2005

Drug/Important Bio-Agent (IBA)

6TrabedersenIBA
12/2011 - 01/2005
4Transforming Growth Factor beta (TGF-beta)IBA
12/2011 - 02/2006
4Transforming Growth Factor beta2IBA
12/2011 - 02/2006
3Proteins (Proteins, Gene)FDA Link
11/2013 - 09/2002
2Peptides (Polypeptides)IBA
11/2013 - 09/2002
2Messenger RNA (mRNA)IBA
11/2009 - 09/2002
2Antisense OligonucleotidesIBA
11/2009 - 01/2005
1Caspase 3 (Caspase-3)IBA
11/2013
1CytokinesIBA
11/2013
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
11/2013
1Pharmaceutical PreparationsIBA
12/2011
1Protein Isoforms (Isoforms)IBA
12/2011
1OligodeoxyribonucleotidesIBA
02/2006
1Tretinoin (Retinoic Acid)FDA LinkGeneric
09/2002
1Staphylococcal Protein A (Protein A)IBA
09/2002
1RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
09/2002
1Biological ProductsIBA
09/2002

Therapy/Procedure

4Therapeutics
12/2011 - 01/2005
2Drug Therapy (Chemotherapy)
12/2011 - 11/2009
1Immunomodulation
09/2002